Insulin is a highly anabolic and powerful hormone produced by all human beings and is essential to a well-functioning individual. Although produced naturally by the human body, insulin is often administered exogenously to those suffering from diabetes. Some performance athletes also use it in an effort to grow lean tissue. However, off-label use can be potentially fatal; extreme caution is advised.
Although all human beings naturally produce insulin, exogenous insulin first appeared in the 1920’s. This was not a synthetic model, but rather extracted from the pancreas of dogs and latter cattle and pigs. While purity was a major issue of concern, the use of exogenous insulin was highly praised as it would save the lives of numerous individuals. Diabetes without insulin treatment can easily be fatal, and while animal extract isn’t pure any impurity issues were considered worth the risk when death was the alternative. However, by the 1970’s purity issues had been greatly resolved, and in 1975 Ciba would introduce the first batches of synthetic insulin to the market. A few years later in 1982, the synthetic version would be perfected even more with the introduction of Humulin-R, which is a perfect copy of human insulin and approved by the FDA.
Insulin Functions & Traits:
Insulin is produced by the pancreas and is officially classified as a peptide hormone. On its functional basis, insulin is responsible for the utilization and regulation of glucose, amino acids and fatty acids. It is also responsible for preventing the metabolic breakdown of glycogen, fat and protein.
For the diabetic patient, there are two types of diabetes that can make insulin necessary. Type I diabetes patients, normally a condition that occurs naturally, do not produce enough insulin on their own to meet their body’s needs. Type II diabetes patients do naturally produce insulin, but the body does not recognize it at the cell site, or at least not at a suitable level. Type II diabetes is most commonly brought on by obesity.
As a peptide hormone secreted by the pancreas, insulin in a positive fashion acts on the liver in order to stimulate the formation of glycogen to glucose. This action further inhibits the formation of non-carbohydrates to glucose. From here, insulin actively promotes the facilitated diffusion of glucose through cells, which has the ability to promote muscle tissue growth. High levels of insulin have been directly linked to enhanced protein synthesis. High levels of insulin have also shown to significantly promote increased bone density as well as increasing the production of Insulin-Like Growth Factor-1 (IGF), a highly anabolic hormone in its own right and structurally similar to insulin.
The functions and traits of insulin do not end there; this hormone has been shown to facilitate an increase in Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). With this increase in LH and FSH, this can potentially increase the production of testosterone in the body. Although the LH and FSH promotion is not notably strong, it is notable enough to mention.
Effects of Insulin:
Regardless of the type of diabetes an individual may suffer from, regulating the control of blood sugar can largely sum up the effects of insulin. Due to its strong anabolic and anti-catabolic properties, insulin can also be beneficial to various athletes. Unfortunately, the use of exogenous insulin for off-label use, those who do not suffer from diabetes, has the potential to promote significant body fat gain. It can also lead to an untimely death if the proper steps of use are not followed.
Regardless of the risk, due to the anabolic and anti-catabolic effects of insulin, some athletes find the hormone worthwhile. However, it can only be worthwhile if body fat is controlled. While perhaps a bit simplified, when insulin levels are high the body’s ability to burn stored body fat is greatly decreased. Due to the potential negative effects of insulin on the metabolism, those supplementing for performance purposes will need to hold to a strict diet that is well planned and thought out. The individual will want to be careful with his calories and fat intake. This will help to ensure glucose and protein is stored in the muscle tissue rather than adipose tissue. Due to the need to control the metabolic effects and maximize the anabolic effects of insulin, the individual will find the best time to take insulin is immediately following an intense weight training session. When administered, this should be accompanied by food; we’ll go over this in the administration section.
Due to the effects of insulin on anabolism, large amounts of lean muscle mass can be built in a relatively short period of time. It is hard for many men to control the potential body fat gain, but it can be done under the right circumstances. The use of anabolic steroids along with insulin as well as Human Growth Hormone (HGH) is normally advised in a performance setting. This will not only promote more growth, but the addition of anabolic steroids and HGH will help the individual tremendously as it pertains to controlling body fat.
Side Effects of Insulin:
There are possible side effects of insulin, and primarily they will surround hypoglycemia. For the diabetic patient, this is generally not a major issue with proper dosing; however, it is a risk in a performance setting. On its surface, hypoglycemia may not sound all that bad, but this can carry with it many possible effects. Due to a hypoglycemic reaction, the side effects of insulin can be quite extensive and even lead to death.
Hypoglycemia is a condition in which blood glucose levels fall to low and is the primary side effect of insulin. There are many symptoms associated with hypoglycemia, the primary symptoms include:
Dizziness
Hunger
Drowsiness
Blurred Vision
Depression
Sweating
Heart Palpitations
Tingling of the Hands, Feet, Lips or Face
Loss of Focus
Headaches
Lightheadedness
Anxiety
Irritability
Slurred Speech
Personality Changes
Unsteady Movements
If the primary symptoms of hypoglycemia occur, which are the primary side effects of insulin, the individual should immediately consume fast acting or simple carbohydrates. Candy, a sugary drink or juice or related combinations are always good choices. Regardless of such symptoms occurring or not, the individual should not go to sleep after administering insulin. If you begin to feel drowsy, this is a good indicator that you need more carbohydrates. If you ignore this warning and go to sleep after administering insulin, you may reach a hypoglycemic state in your sleep, which if not remedied (you can’t remedy it if you’re asleep) could be fatal. If for any reason severe hypoglycemia sets in, you should immediately seek out medical attention. For this reason, due to the potential side effects of insulin you should not administer the hormone when you are alone. You should always have someone present just to be on the safe side.
A common question many have pertaining to the side effects of insulin is how serious is severe hypoglycemia? How concerned should you be about such a condition? Although it is easy to correct in most cases, it is possible to slip into a diabetic coma, and you may not wake up. There have been several deaths linked to performance based insulin use over the years, and it’s hard to get any more serious than death.
Beyond hypoglycemia, there are other possible side effects of insulin that surround an allergic reaction. Some individuals will note swelling, itching, irritation or tenderness at the injected site. While these effects are possible they are also rare. Even less common but still possible includes rash, shortness of breath, rapid heart rate, wheezing or a drop in blood pressure. If such side effects of insulin occur, while rare, medical attention should be sought out immediately.
The final side effect of insulin is the localized enhancement of adipose tissue.
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