PHARMA TEST E300 (Testosterone Enanthate) is one of the most effective mass-building anabolics available and is highly recommended as the foundation of any mass-building cycle. Testosterone promotes health and well-being by enhancing libido, energy, immunity, fat loss, lean muscle mass, bone density, and potentially protecting against heart disease. It combines excellently with many other oral and injectable compounds as part of a potent stack.

With a half-life of around 5-7 days, PHARMA TEST E300 is a slow-release ester, similar to PHARMA TEST C250 (Testosterone Cypionate).

Synthetic testosterone was first synthesized in 1935 by German biochemist Adolf Butenandt and Swiss chemist Leopold Ruzicka, who both received a Nobel Prize for their work.

Testosterone is the primary male sexual hormone, directly affecting testicle and prostate development, muscle tissue building, bone density, and strength. It is responsible for numerous functions in the human body, including overall health, well-being, enhanced libido, energy, immunity, preventing osteoporosis, and potential protection against heart disease. Maintaining higher testosterone levels in elderly men has been shown to improve parameters that reduce cardiovascular disease risk, such as increased lean body mass, decreased visceral fat mass, decreased total cholesterol, and glycemic control. Testosterone also influences behavior, mood, romantic relationships, and cognitive functions like attention, memory, and spatial ability. Low testosterone levels may be a risk factor for cognitive decline and dementia, making it a key component in anti-aging therapies.

Athletes highly favor testosterone for its ability to promote strong increases in muscle mass and strength. As a naturally occurring hormone, it remains the most popular anabolic steroid and is typically used as the base of all cycles and stacks.

In bodybuilding, testosterone is almost always used as an injectable ester or suspension due to poor oral bioavailability and the impracticality of high-dose transdermal or sublingual delivery. All testosterone forms consist of the active agent testosterone plus an ester, which determines release time and duration of the compound’s active life. Long esters release the active agent slowly, providing a stable hormone level for an extended period without creating peaks.

In men, approximately 5% of testosterone undergoes 5α-reduction to form the more potent androgen, dihydrotestosterone (DHT), also known as androstanolone. About 0.3% of testosterone is converted into estradiol (the primary female sex hormone) by aromatase, an enzyme expressed in the brain, liver, and adipose tissues. To avoid respective side effects, it is recommended to perform blood work and take aromatase inhibitors (preferably anastrozole) during the cycle and SERMs (clomifene, toremifene) during post-cycle therapy (PCT).